Established and novel in vitro cell systems
The aim of WP2 is to develop a tiered system of single and multi-cell in vitro test systems that can be used to predict whether or not an individual test compound has the propensity to cause human DILI. These will address a broad variety of mechanisms and will range from single cell models, such as hepatocytes, to complex multi-cellular culture devices.
Physiological characterization of prioritised single cell systems and multi-cell models
Evaluation of toxic/adaptive responses to test compounds.
Development and evaluation of novel in vitro systems with improved predictivity.
Validation of selected systems for use in prediction of DILI in man.