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MIP-DILI poster

Please find the MIP-DILI project poster in the following link: 

Please download the full pdf

MIP-DILI overview

Please find the MIP-DILI project overview in the following link:

Please download the full pdf

 

EUROTOX 2014

50th Congress of the European Societies of Toxicology - EUROTOX 2014
Location : at the Edinburgh International Conference Centre, Edinburgh, UK
Duration : 4 days, From 7/09/2014 to 10/09/2014

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Abstracts of Workshop 12:Mechanistic approaches to understanding drug induced liver injury: IMI’s MIP-DILI project.
Special Issue at Toxicology Letters
Volume 229, Supplement, Pages S1-S252 (10 September 2014)
Abstracts of the 50th Congress of the European Societies of Toxicology (EUROTOX)
http://www.sciencedirect.com/science/journal/03784274/229/supp/S 

 

2nd MIP-DILI Annual Meeting

Location : Hilton Hotel Manchester Airport, UK
Duration : 2 days, From 19/03/2014 to 20/03/2014

Workshop III

Location : at the Institut de Recherches Internationales Servier, Surenses, Paris, France
Duration : 2 days, From 22/10/2013 to 23/10/2013

Event 2013: 1st MIP-DILI Annual Meeting

1st  MIP-DILI Annual Meeting
Location : Amsterdam, Nederlands
Duration : 2 days, From 27/02/2013 to 28/02/2013
The 1st MIP-DILI Annual Meeting will take place on 27 – 28 February 2013 in Amsterdam.
The event will be organized at the  Vrije University Amsterdam -

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Overtaking the DILI Model

Nature Reviews Drug Discovery 11, 585-586 (August 2012) | doi:10.1038/nrd3818

The damage hit without warning. Of the 40 healthy volunteers who had enrolled in a Phase I trial for panadiplon, an experimental anxiety drug, 11 quickly showed liver injury, even though rat, dog and monkey studies hadn't hinted at any toxicity issues. http://www.nature.com/nrd/journal/v11/n8/full/nrd3818.htm

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MIP-DILI press release IMI JU

Many medicines are harmful to the liver, and drug-induced liver injury (DILI) now ranks as the leading cause of liver failure and transplantation in western countries. However, predicting which drugs will prove toxic to the liver is extremely difficult, and often problems are not detected until a drug is already on the market. For the first time, the IMI project MIP-DILI brings together Europe’s top industrial and academic experts in the field.

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Drugs that are kinder to the liver
New collaborative project "MIP DILI" Mechanism-based integraded systems for the prediction of drug indeced liver injury.

A new €32 million project aimed at understanding drug-induced liver injury is the latest of several collaborative efforts that could help drug firms better test for candidate-killing toxicity signals.
Many medicines are harmful to the liver, and drug-induced liver injury (DILI) now ranks as the leading cause of liver failure and transplantation in western countries. However, predicting which drugs will prove toxic to the liver is extremely difficult, and often problems are not detected until a drug is already on the market. For the first time, the IMI project MIP-DILI brings together Europe’s top industrial and academic experts in the field.

Please download the full pdf