In Vivo model systems
- The evaluation of chemical stress induced by drugs in liver cells, in particular biological perturbation observed under circumstances not associated with overt toxicity as assessed by standard histopathology and clinical chemistry (i.e. associated with adaptive responses)
- The consideration of the role of inflammation, particularly infective inflammation, as an important factor in DILI as it occurs in patients
It is believed that such an approach will furnish animal models that are complementary to those currently in uses by the pharmaceutical industry, and will help predict human-specific forms of DILI including those forms, which are idiosyncratic in nature.
Development of new in vivo models based on infectious (or sterile) inflammation in the liver, together with mechanistic understanding.
Determining utility of reporter and humanised mice for predicting oxidative stress and DILI in response to drug challenge.
Provision of new knowledge to be applied in the development of in vitro models in WP2.